Transmission inter-espèces, adaptation à l’homme et pathogénicité des virus influenza d’origine animale
| Autor: | Nadia Naffakh, D Moisy, Sandie Munier, Daniel Marc |
|---|---|
| Přispěvatelé: | Génétique moléculaire des virus à ARN, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Infectiologie Animale et Santé Publique - IASP (Nouzilly, France), Institut National de la Recherche Agronomique (INRA), Fonds pour la Recherche sur l’Influenza Aviaire (FRIA-08-008-03), Infectiologie Animale et Santé Publique (UR IASP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2010 |
| Předmět: |
Disease reservoir
MESH: Swine Diseases viruses Reassortment Pathogenesis MESH: Virulence medicine.disease_cause Zoonosis virus influenza aviaire MESH: Animals MESH: Disease Outbreaks MESH: Phylogeny MESH: Swine MESH: Orthomyxoviridae Infections MESH: Orthomyxoviridae 0303 health sciences Transmission (medicine) MESH: Influenza Human General Medicine 3. Good health Interspecies transmission spectre d'hôte MESH: Birds MESH: Zoonoses Viral genome replication zoonose Biology H5N1 genetic structure interaction entre espèces Virus 03 medical and health sciences MESH: Influenza in Birds medicine Influenza viruses MESH: Species Specificity Gene Host-specificity 030304 developmental biology MESH: Disease Reservoirs MESH: Humans [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health Pandemic 030306 microbiology transmission de la maladie MESH: Adaptation Physiological MESH: Receptors Virus MESH: Viral Proteins Virology Influenza A virus subtype H5N1 MESH: Ribonucleoproteins [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Viral Tropism |
| Zdroj: | Pathologie Biologie Pathologie Biologie, Elsevier Masson, 2010, 58 (2), pp.e59-e68. ⟨10.1016/j.patbio.2010.01.012⟩ Pathologie Biologie, 2010, 58 (2), pp.e59-e68. ⟨10.1016/j.patbio.2010.01.012⟩ |
| ISSN: | 0369-8114 |
| Popis: | The emergence in 2009 of a novel A(H1N1)v influenza virus of swine origin and the regular occurrence since 2003 of human cases of infection with A(H5N1) avian influenza viruses underline the zoonotic and pandemic potential of type A influenza viruses. Influenza viruses from the wild aquatic birds reservoir usually do not replicate efficiently in humans. Domestic poultry and swine can act as intermediate hosts for the acquisition of determinants that increase the potential of transmission and adaptation to humans, through the accumulation of mutations or by genetic reassortment. The rapid evolution of influenza viruses following interspecies transmission probably results from the selection of genetic variations that favor optimal interactions between viral proteins and cellular factors, leading to an increased multiplication potential and a better escape to the host antiviral response. Whereas influenza viruses usually cause asymptomatic infections in wild aquatic birds, they may be highly pathogenic in other species. Molecular determinants of host-specificity and pathogenesis have been identified in most viral genes, notably in genes that encode viral surface glycoproteins, proteins involved in the viral genome replication, and proteins that counteract the host immune response. However, our knowledge of these numerous and interdependant determinants remains incomplete, and the molecular mechanisms involved are still to be understood. |
| Databáze: | OpenAIRE |
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