Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
| Autor: | Younghyon Andrew Eom, Ji Hwoon Baek, Hyeonjun Kim, Youseong Kim, Jaesuk Koh, Liching Chiang, Seung Hee Lee, Hyungil Jung, Geonwoo Kang, Ye Eun Lee, Mingyu Jang, Ja Hyun Ryu, Huisuk Yang, Suyong Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Skin barrier Adenosine Transdermal Patch Dermatology Natural oils Administration Cutaneous In vitro analysis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems medicine Animals Humans Tissue Distribution Horses Wrinkle Skin Biological Products integumentary system Chemistry Single patch Middle Aged Water Loss Insensible Elasticity Skin Aging Needles 030220 oncology & carcinogenesis Skin penetration Drug delivery medicine.symptom human activities Hydrophobic and Hydrophilic Interactions Oils Biomedical engineering medicine.drug |
| Zdroj: | Journal of cosmetic dermatology. 18(3) |
| ISSN: | 1473-2165 |
| Popis: | Background Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, for example, natural oils or ceramides, enrich the skin barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives In the present study, we combined a topical formulation and a DMN patch to perform two-phase delivery comprising a lipophilic formulation and hydrophilic compound-loaded DMNs to improve skin barrier status and the efficacy of drug delivery. Methods Horse oil-spread and adenosine-loaded DMN arrays were developed in a single patch (HOS-Ad-DMN patch). In vitro analysis was conducted to confirm the successful delivery of the compositions. Clinical assessments were conducted on the lateral canthus of 20 women to compare the efficacy of HOS-Ad-DMN patches with that of adenosine-loaded DMN patches (Ad-DMN patches). Results Adenosine was delivered via the DMNs after skin penetration and horse oil was delivered successfully into the skin through the microchannels created by the Ad-DMNs. Compared with Ad-DMN patches, HOS-Ad-DMN patches significantly improved skin elasticity, hydration, dermal density, and wrinkles. No adverse events were observed. Conclusion HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|