Scedosporium apiospermumkeratitis treated with itraconazole
| Autor: | Mehmet Ali Saraçli, U. Erdem, A. Gonlum, S. T. Yildiran |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Antifungal Agents Itraconazole Microbial Sensitivity Tests Keratitis Microbiology Minimum inhibitory concentration Drug Resistance Fungal Amphotericin B Humans Medicine Scedosporium Fluconazole biology business.industry Scedosporium apiospermum General Medicine Eye infection biology.organism_classification medicine.disease Pseudallescheria boydii Treatment Outcome Infectious Diseases Mycetoma business Eye Infections Fungal medicine.drug |
| Zdroj: | Medical Mycology. 41:111-114 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1080/mmy.41.2.111.114 |
| Popis: | Mycotic keratitis usually occurs in conjunction with trauma to the cornea. Scedosporium apiospermum, a dematiaceous fungus linked to the teleomorph Pseudallescheria boydii is not a common agent of mycotic keratitis. A 22-year old male patient with mycotic keratitis due to S. apiospermum is presented. In in vitro susceptibility testing, the isolate showed resistance against amphotericin B (minimum inhibitory concentration [MIC] 16 microg ml(-1)) but was susceptible to itraconazole (ITC) and fluconazole with MICs of 0.125 microg ml(-1) and 4 microg ml(-1), respectively. The patient was cured clinically after ITC treatment and surgical intervention. Azoles may be superior for eliminating S. apiospermum from infected ocular sites. |
| Databáze: | OpenAIRE |
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