| Autor: |
Harald Olsen, Jørg Mørland |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Acta Medica Scandinavica. 210:119-124 |
| ISSN: |
0001-6101 |
| DOI: |
10.1111/j.0954-6820.1981.tb09786.x |
| Popis: |
The acetylation of sulfadimidine was studied in 152 healthy volunteers (29 Lapps, 73 Norwegians and 50 South Norwegians) by means of fraction acetylated sulfadimidine and drug half-life. The distribution of rapid acetylators was different among Lapps (72%) and South Norwegians (44%) (p less than 0.01). The North Norwegians resembled the South Norwegians, but some regional approach to the Lappish pattern was found. Great interindividual differences in the half-lives were demonstrated. The mean half-life (+/- S.E.M.) was 384 +/- 17 min in slow acetylators and 148 +/- 8 min in rapid acetylators. Among participants with half-lives of sulfadimidine less than 420 min and intraindividual correlation with fraction acetylated sulfadimidine was found. The distribution of fraction acetylated sulfadimidine was bimodal while the distribution of half-lives was suggested to be trimodal. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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