Herd immunity to Newcastle disease virus in poultry by vaccination

Autor: Annemarie Bouma, T H F Fabri, Elly Katsma, Leo A. den Hartog, Guus Koch, Michiel van Boven
Přispěvatelé: Animal Sciences Group, Wageningen University and Research [Wageningen] (WUR), Faculty of Veterinary Medicine, Utrecht University [Utrecht], Animal Health Service, Department of Virology, Central Institute for Animal Disease Control, Virology, CIDC-Lelystad
Rok vydání: 2008
Předmět:
Immunity
Herd
040301 veterinary sciences
Newcastle Disease
Newcastle disease virus
Biology
medicine.disease_cause
Models
Biological
size
Newcastle disease
Virus
Disease Outbreaks
Herd immunity
0403 veterinary science
03 medical and health sciences
CVI - Divisie Virologie
CIDC - Division Virology
Food Animals
Immunity
medicine
Animals
030304 developmental biology
0303 health sciences
General Immunology and Microbiology
Transmission (medicine)
CIDC - Divisie Virologie
Vaccination
transmission
Life Sciences
Outbreak
Viral Vaccines
Original Articles
04 agricultural and veterinary sciences
biology.organism_classification
Virology
quantification
Influenza A virus subtype H5N1
3. Good health
ASG Infectieziekten
Immunology
challenge
chickens
Animal Science and Zoology
avian influenza
CVI - Division Virology
Zdroj: Avian Pathology
Avian Pathology, Taylor & Francis, 2008, 37 (01), pp.1-5. ⟨10.1080/03079450701772391⟩
Avian Pathology 37 (2008) 1
Avian Pathology, 37(1), 1-5
ISSN: 1465-3338
0307-9457
Popis: International audience; Newcastle disease virus is an economically important disease of poultry for which vaccination is applied as a preventive measure in many countries. Nevertheless, outbreaks have been reported in vaccinated populations. This suggests that either the vaccination coverage level is too low or that vaccination does not provide perfect immunity, allowing the virus to spread in partially vaccinated populations. Here we study the requirements of an epidemiologically effective vaccination program against Newcastle disease in poultry, based on data from experimental transmission studies. The transmission studies indicate that vaccinated birds with low or undetectable antibody titres may be protected against disease and mortality but that infection and transmission may still occur. In fact, our quantitative analyses show that NDV is highly transmissible in poultry with low antibody titres. As a consequence, herd immunity can only be achieved if a high fraction of birds (>85%) has a high antibody titre (log2 haemagglutination inhibition titre≥3) after vaccination. We discuss the implications for the control of Newcastle disease virus in poultry by vaccination.
Databáze: OpenAIRE
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