Hematological, biochemical, and toxicopathic effects of subchronic acetamiprid toxicity in Wistar rats
| Autor: | Rakia Bhouri, Amira Sallem, Fadoua Neffati, Intissar Grissa, Zohra Haouas, Emna Kerkeni, Meriem Mehdi, Mohssen Hassine, Mohamed Fadhel Najjar, Lobna Ezzi, Hassen Ben Cheikh, Sana Chakroun |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Insecticides Pyridines Health Toxicology and Mutagenesis 010501 environmental sciences Pharmacology medicine.disease_cause 01 natural sciences Acetamiprid Superoxide dismutase Lipid peroxidation Neonicotinoids 03 medical and health sciences chemistry.chemical_compound Oral administration Lactate dehydrogenase medicine Animals Environmental Chemistry Aspartate Aminotransferases Rats Wistar 0105 earth and related environmental sciences Hematologic Tests L-Lactate Dehydrogenase biology Superoxide Dismutase Alanine Transaminase Organ Size General Medicine Alkaline Phosphatase Catalase Pollution Rats 030104 developmental biology Liver chemistry Biochemistry Toxicity biology.protein Lipid Peroxidation Oxidative stress |
| Zdroj: | Environmental Science and Pollution Research. 23:25191-25199 |
| ISSN: | 1614-7499 0944-1344 |
| Popis: | Acetamiprid is one of the most widely used neonicotinoids. This study investigates toxic effects of repeated oral administration of three doses of acetamiprid (1/20, 1/10, and 1/5 of LD50) during 60 days. For this, male Wistar rats were divided into four different groups. Hematological, biochemical, and toxicopathic effects of acetamiprid were evaluated. According to the results, a significant decrease in the body weight gain at the highest dose 1/5 of LD50 of acetamiprid was noticed. An increase in the relative liver weight was also observed at this dose level. The hematological constituents were affected. A significant decrease in RBC, HGB, and HCT in rats treated with higher doses of acetamiprid (1/10 and 1/5 of LD50) was noted. However, a significant increase in WBC and PLT were observed at the same doses. Furthermore, acetamiprid induced liver toxicity measured by the increased activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphates (ALPs), and lactate dehydrogenase (LDH) which may be due to the loss of hepatic membrane architecture and hepatocellular damage. In addition, exposure to acetamiprid resulted in a significant decrease in the levels of superoxide dismutase and catalase activities (p ≤ 0.01) with concomitant increase in lipid peroxidation in rat liver. These findings highlight the subchronic hepatotoxicity of acetamiprid. |
| Databáze: | OpenAIRE |
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