Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
| Autor: | Terri L. Hanner, Dean L. Antonson, James V. Lupo, Rosemary J. Young, David B. Whitney, Jon A. Vanderhoof |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Diarrhea
Male medicine.medical_specialty Lactobacillus GG Lactobacillus casei medicine.drug_class Antibiotics Placebo law.invention Probiotic Double-Blind Method law Internal medicine medicine Humans Child biology business.industry Incidence Probiotics Incidence (epidemiology) Infant biology.organism_classification Anti-Bacterial Agents Surgery Lacticaseibacillus casei Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom Antibiotic-associated diarrhea business |
| Zdroj: | The Journal of Pediatrics. 135:564-568 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(99)70053-3 |
| Popis: | Objective: The objective of this study was to determine the efficacy of Lactobacillus casei sps. rhamnosus (Lactobacillus GG) (LGG) in reducing the incidence of antibiotic-associated diarrhea when coadministered with an oral antibiotic in children with acute infectious disorders. Study design: Two hundred two children between 6 months and 10 years of age were enrolled; 188 completed all phases of the protocol. LGG, 1 × 1010 – 2 × 1010 colony forming units per day, or comparable placebo was administered in a double-blind randomized trial to children receiving oral antibiotic therapy in an outpatient setting. The primary caregiver was questioned every 3 days regarding the incidence of gastrointestinal symptoms, predominantly stool frequency and consistency, through telephone contact by blinded investigators. Results: Twenty-five placebo-treated but only 7 LGG-treated patients had diarrhea as defined by liquid stools numbering 2 or greater per day. Lactobacillus GG overall significantly reduced stool frequency and increased stool consistency during antibiotic therapy by the tenth day compared with the placebo group. Conclusion: Lactobacillus GG reduces the incidence of antibiotic-associated diarrhea in children treated with oral antibiotics for common childhood infections. (J Pediatr 1999;135:564-8) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect