Polymer mimics of biomacromolecular antifreezes
| Autor: | Ben Graham, Matthew I. Gibson, Christopher D. Stubbs, Trisha L. Bailey, Caroline I. Biggs, Alice E. R. Fayter |
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| Rok vydání: | 2017 |
| Předmět: |
Science
Fish species General Physics and Astronomy 02 engineering and technology Review Article 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Cryopreservation Antifreeze protein QD lcsh:Science chemistry.chemical_classification Multidisciplinary Ice crystals QH General Chemistry Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Transplantation chemistry Biophysics lcsh:Q 0210 nano-technology human activities Macromolecule |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2041-1723 |
| Popis: | Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced. Ice crystal growth is a major problem in cell and tissue cryopreservation for transplantation, transfusion, icing of aircraft wings and many other applications. Here the authors review the emerging field of synthetic macromolecular mimics of antifreeze proteins that can be used overcome such problems. |
| Databáze: | OpenAIRE |
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