An LC-MS/MS Analysis of Opiate Residues on Thomas Chatterton’s (1752-1770) Memorandum Book:Did he Die from a Laudanum Overdose?
| Autor: | Paul J. Gates, Michael L. Doble |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
media_common.quotation_subject Memorandum medicine.medical_treatment Laudanum 01 natural sciences Biochemistry Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Lc ms ms Electrochemistry medicine Environmental Chemistry Humans Spectroscopy media_common Inquest Literature business.industry Books Opiate Alkaloids 010401 analytical chemistry 030208 emergency & critical care medicine Art humanities 0104 chemical sciences Analgesics Opioid Premature death business Chromatography Liquid |
| Zdroj: | Gates, P J & Doble, MI 2020, ' An LC-MS/MS Analysis of Opiate Residues on Thomas Chatterton’s (1752-1770) Memorandum Book : Did he Die from a Laudanum Overdose? ', Analyst, vol. 2020, pp. 8104-8110 . https://doi.org/10.1039/D0AN01662D |
| DOI: | 10.1039/D0AN01662D |
| Popis: | 250 years after his death, Thomas Chatterton continues to create discussion amongst the literati and enchant the people of Bristol. The controversy of his life was entwinned with his writings where he passed his work off as that of a fictional medieval poet – Thomas Rowley. His premature death at the age of 17 in 1770 is also shrouded in controversy – did he commit suicide from arsenic poisoning (as stated at the original inquest into his death), or did he accidentally overdose on laudanum (as suggested by the 1947 forensic analysis)? The purpose of this study is to use state-of-art analytical methods (namely ultra-high-performance liquid chromatography tandem mass spectrometry using an Orbitrap mass spectrometer) to investigate the brown stain found on his memorandum book. The conclusion of this study is that that stain is made up of, amongst other things, 18 opiate and 1 opioid degradation product – 9 of which are previously unpublished, and that the spillage was indeed due to laudanum. |
| Databáze: | OpenAIRE |
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