Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection
| Autor: | I. Striz, Irena Tycova, Ondrej Viklicky, Eva Honsova, Veronika Svachova, Alena Sekerkova, Marketa Rodova, Janka Slatinska, Eva Cecrdlova, Petra Hruba |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Graft Rejection Male 0301 basic medicine Time Factors Adolescent medicine.medical_treatment Plasma Cells Naive B cell B-Lymphocyte Subsets 030230 surgery CD38 Sensitivity and Specificity Immunoglobulin D Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Humans Medicine Prospective Studies Child B cell Kidney transplantation Aged Immunosuppression Therapy Transplantation biology business.industry Precursor Cells B-Lymphoid CD24 Antigen Immunosuppression Middle Aged Allografts medicine.disease ADP-ribosyl Cyclase 1 Kidney Transplantation Transplant Recipients Tumor Necrosis Factor Receptor Superfamily Member 7 030104 developmental biology medicine.anatomical_structure Child Preschool Immunology biology.protein Female business Immunologic Memory |
| Zdroj: | Transplant International. 29:540-548 |
| ISSN: | 0934-0874 |
| Popis: | B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high) CD38(high) CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+) IgD(+) CD27(-) naive B cells did not change within follow-up. IgM(+) CD27(+) nonswitched memory B cells and IgM(-) CD27(+) switched memory B cells increased on post-operative day 7. IgM(-) CD38(high) CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation. |
| Databáze: | OpenAIRE |
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