Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats
| Autor: | Hsin-Chih Lai, Shyh-Shyun Huang, Yi-Chuan Chen, Chia-Chen Lu, Guan-Jhong Huang, Chun-Hung Yang, Heng-Yuan Chang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Carcinogenesis Pharmacology Protective Agents medicine.disease_cause 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Liver Neoplasms Experimental 0302 clinical medicine parasitic diseases medicine Animals Diethylnitrosamine Pharmacology (medical) Ethanol Plant Extracts Liver Carcinogenesis Basidiomycota Glutamic-Oxaloacetic Transaminase General Medicine 2-Acetylaminofluorene Cytoprotection Pathophysiology Rats Phellinus Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Phellinus merrillii |
| Zdroj: | Chinese Journal of Integrative Medicine. 23:117-124 |
| ISSN: | 1993-0402 1672-0415 |
| Popis: | To study whether the ethanol extract of Phellinus merrillii (EPM) has chemopreventive potential against liver carcinogenesis. Thirty male Spraque-Dawley rats were randomly divided into control group, EPM control group, hepatocarcinoma control group, low-dose EPM group and high-dose EPM group, 6 in each group. Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated. Basic pathophysiological and histological examinations, together with the serum levels of glutamic oxaloacetic transaminase (sGOT), glutamic pyruvic transaminase (sGPT) and gamma-glutamyl transpeptidase (γ-GT) were measured. Treatment of EPM at the concentration of 2 g/kg body weight in the diet for 8 weeks clearly prevented the development of carcinogenesis and reduced the levels of sGOT, sGPT, and serum γ-GT of rats as compared with the hepatocarcinoma control group (P |
| Databáze: | OpenAIRE |
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