Influence of +299G>A and +62G˃A resistin gene promoter variants on cardiovascular risk in Egyptian women with systemic lupus erythematosus

Autor: Dina Said, Ayman E. Ali, Nearmeen M. Rashad, Reem M. Allam, Nesreen M. Mohy, Hala G. Abomandour
Rok vydání: 2019
Předmět:
Zdroj: Egyptian Rheumatologist, Vol 41, Iss 3, Pp 215-220 (2019)
ISSN: 1110-1164
DOI: 10.1016/j.ejr.2018.11.005
Popis: Background: Cardiovascular diseases (CVDs) are major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients. Resistin is an inflammatory adipocytokine associated with insulin resistance and an increased risk of CVD. Aim of the work: To study the possible role of resistin (RETN) +299A>G and +62G˃A gene polymorphisms in the development of CVDs among Egyptian SLE patients and their impact on cardio metabolic risk and disease activity. Patients and methods: +299A>G and +62G˃A genes polymorphisms were assessed in 140 patients and 100 controls by polymerase chain reaction (PCR). The carotid intima-media thickness (CIMT) was measured. SLE disease activity index (SLEDAI) was assessed. Serum resistin, homeostasis model assessments (HOMA-IR and HOMA-β), fibrinogen and homocysteine were measured. Results: The mean age of patients was 31.1 ± 7.6 years and disease duration 5.4 ± 2.5 years. Serum resistin was significantly increased in patients (4.9 ± 0.2 ng/ml) compared to control (3.02 ± 0.9 ng/ml) (p A were significantly higher in patients than control (37.9% vs 10% and 63.6% vs 33.5%; p A GA and AA patients compared to GG (p
Databáze: OpenAIRE