Effect of an Epidermal Growth Factor-Containing Cream on Postinflammatory Hyperpigmentation After Q-Switched 532-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment
| Autor: | Hye-Rim Moon, Kee Chan Moon, Gyeong-Hun Park, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Do Young Rhee, Sung Eun Chang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Cream chemistry.chemical_element Dermatitis Lasers Solid-State Dermatology Neodymium Hyperpigmentation Epidermal growth factor Humans Medicine Aged Lentigo Transepidermal water loss Epidermal Growth Factor business.industry Laser treatment General Medicine Middle Aged Water Loss Insensible chemistry Erythema Skin color Female Surgery Dermatologic Agents medicine.symptom business Wound healing Postinflammatory hyperpigmentation |
| Zdroj: | Dermatologic Surgery. 41:131-135 |
| ISSN: | 1076-0512 |
| DOI: | 10.1097/dss.0000000000000197 |
| Popis: | Background Topical application of epidermal growth factor (EGF) promotes wound healing and may reduce the risk of laser-induced postinflammatory hyperpigmentation (PIH). Objective To investigate the effect of an EGF-containing cream on the incidence of laser-induced PIH. Methods Twenty-five Korean patients with senile lentigines were recruited and underwent 532-nm Q-switched Nd:YAG laser treatment. Postoperatively, patients applied either an EGF-containing cream or a control cream to the laser-treated area. Skin color and transepidermal water loss (TEWL) were measured on Days 0, 3, 7, and 35 using a Mexameter and Tewameter, respectively. Results The EGF-containing cream resulted in a nonsignificant reduction in the laser-induced increase in TEWL (p = .052 on Day 7) but significantly decreased the melanin index and incidence of PIH on Day 35 (p = .031 and p = .027, respectively). Conclusion Epidermal growth factor-containing creams may be an effective measure to prevent laser treatment-induced PIH in Asian patients. |
| Databáze: | OpenAIRE |
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