Extracellular Vesicles in chondrogenesis and Cartilage regeneration
| Autor: | Amir Abbas Momtazi-Borojeni, Hong Song, Jianhua Wang, Zhijie Feng, Jiasong Zhao, Yimin Liang, Jun Cheng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Reviews Review Exosome Chondrocyte 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Tissue engineering medicine Animals Humans Chemistry Cartilage Regeneration (biology) Mesenchymal stem cell Cell Biology Chondrogenesis Microvesicles Cell biology 030104 developmental biology medicine.anatomical_structure Cartilage regeneration 030220 oncology & carcinogenesis Regenerative medicine Molecular Medicine |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | Extracellular vesicles (EVs), mainly exosomes and microvesicles, are bilayer lipids containing biologically active information, including nucleic acids and proteins. They are involved in cell communication and signalling, mediating many biological functions including cell growth, migration and proliferation. Recently, EVs have received great attention in the field of tissue engineering and regenerative medicine. Many in vivo and in vitro studies have attempted to evaluate the chondrogenesis potential of these microstructures and their roles in cartilage regeneration. EVs derived from mesenchymal stem cells (MSCs) or chondrocytes have been found to induce chondrocyte proliferation and chondrogenic differentiation of stem cells in vitro. Preclinical studies have shown that exosomes derived from MSCs have promising results in cartilage repair and in cell‐free therapy of osteoarthritis. This review will focus on the in vitro and in vivo chondrogenesis and cartilage regeneration of EVs as well as their potential in the treatment of osteoarthritis. |
| Databáze: | OpenAIRE |
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