COVID-19 Associated Collapsing FSGS in an APOL1 Homozygous Transplant Recipient After Successful COVID Vaccination: A Case Report
| Autor: | Thomas R McCune, Jolanta Kowalewska, Shirui Chen |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Collapsing FSGS
medicine.medical_specialty COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) medicine.medical_treatment Transplant recipient SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Article Organ transplantation Immune system IL-2 interleukin-2 Humans Medicine UPCR urine protein-creatinine ratio Transplantation Glomerulosclerosis Focal Segmental business.industry Vaccination FSGS focal segmental glomerulosclerosis COVID-19 Immunosuppression Apolipoprotein L1 Transplant Recipients APOL1 apolipoprotein L1 Immunology Female Surgery Hemodialysis business COVID-19 coronovirus disease 2019 |
| Zdroj: | Transplantation Proceedings |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2021.11.001 |
| Popis: | Organ transplant recipients exhibit lower rates of immune response to coronavirus disease 2019 (COVID-19) vaccination. Even when they do mount a demonstrable antibody response, it is unclear what degree of protection is conferred against the myriad potential complications of COVID-19 infection. We present here a case of a kidney transplant recipient who was homozygous for APOL1 risk alleles on low-dose immunosuppression who developed an antibody response to COVID-19 vaccination and subsequently acquired COVID-19 infection. Although she experienced relatively minor effects in other organ systems, she developed severe collapsing focal segmental glomerulosclerosis that left her dependent on hemodialysis on hospital discharge. This suggests that COVID-19 vaccination may not provide protection from infection-associated focal segmental glomerulosclerosis in patients with APOL1 risk alleles. |
| Databáze: | OpenAIRE |
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