G protein‐coupled receptor 40 expression in human melanoma – correlation with tumour thickness, AJCC stage and survival
| Autor: | Roland Kaufmann, Pia Kleimann, Jutta Müller, Katja Härle, Markus Meissner, Stefan Kippenberger, Jan Ter-Nedden, Melanie Glaser, Johannes Kleemann, Katja Steinhorst, Igor Hrgovic |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine endocrine system Skin Neoplasms Dermatology Receptors G-Protein-Coupled Metastasis 03 medical and health sciences 0302 clinical medicine Free fatty acid receptor 1 Biomarkers Tumor medicine Humans Receptor Melanoma Survival analysis Neoplasm Staging chemistry.chemical_classification Cell growth business.industry Middle Aged medicine.disease Survival Analysis 030104 developmental biology Infectious Diseases chemistry 030220 oncology & carcinogenesis Cancer research Immunohistochemistry Female business Polyunsaturated fatty acid |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 34:285-292 |
| ISSN: | 1468-3083 0926-9959 |
| DOI: | 10.1111/jdv.15924 |
| Popis: | BACKGROUND In melanoma, preclinical data suggest a possible role of polyunsaturated fatty acids inhibiting cell growth. A new target molecule for free fatty acids, the G protein-coupled receptor GPR40, was identified in melanoma cells. OBJECTIVES The aim of this study was to investigate GPR40 expression in human melanocytic tissues and to evaluate its potential as a prognostic marker. METHODS AND RESULTS A total of 114 tissue sections of naevi, primary melanoma and melanoma metastasis were immunohistochemically stained with anti-GPR40. The staining was evaluated, using the immunoreactivity scoring system. Compared to naevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR40 (P |
| Databáze: | OpenAIRE |
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