CSF 5-HIAA and aggression in female macaque monkeys: species and interindividual differences
| Autor: | G. C. Westergaard, P. T. Mehlman, S. J. Suomi, J. D. Higley |
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| Rok vydání: | 1999 |
| Předmět: |
media_common.quotation_subject
Individuality Physiology Impulsivity Serotonergic Macaque Developmental psychology Species Specificity biology.animal medicine Agonistic behaviour Animals media_common Pharmacology biology Aggression Hydroxyindoleacetic Acid Dominance (ethology) Social Dominance nervous system Macaca Female Temperament Serotonin medicine.symptom Psychology Biomarkers |
| Zdroj: | Psychopharmacology. 146:440-446 |
| ISSN: | 0033-3158 |
| DOI: | 10.1007/pl00005489 |
| Popis: | Rationale: While the relationship among CSF 5-HIAA, impulsivity, and aggression is well characterized in males, its investigation in females is limited, and no studies have assessed its generalizability across primates by making simultaneous comparisons between and within closely-related species. Objectives: We tested three hypotheses. First, that female rhesus macaques would have lower CSF 5-HIAA concentrations and be more aggressive than would female pigtailed macaques. Second, that females of both macaque species would exhibit an inverse relationship between interindividual differences in CSF 5-HIAA concentrations and rates of severe aggression. Third, that subjects with high CSF 5-HIAA concentrations would be higher in social dominance within their respective groups than would subjects with low CSF 5-HIAA concentrations. Methods: We obtained CSF samples from 61 individually housed female primates of two closely related species: rhesus macaques (Macaca mulatta) and pigtailed macaques (Macaca nemestrina). We later placed subjects in unisex social groups, and correlated interindividual differences in CSF 5-HIAA with aggression, wounding, and acquisition of social dominance rank. Results: Between-species analyses indicated higher CSF 5-HIAA concentrations in pigtailed macaques, and higher rates of high-intensity aggression, escalated aggression, and wounds requiring medical treatment in rhesus macaques. Within-species analyses indicated that interindividual differences in CSF 5-HIAA concentrations were inversely correlated with escalated aggression and positively correlated with social dominance rank. Conclusions: These findings show that agonistic and social differences between closely-related species are correlated with CNS serotonin activity, as species that show relatively high rates of severe aggression also tend to have low concentrations of CSF 5-HIAA. We conclude that serotonergic functioning plays an important role in controlling impulses that regulate severe aggression and social dominance relationships in both male and female primates, and that between-species differences in agonistic temperament can be predicted by species typical CNS serotonin functioning. |
| Databáze: | OpenAIRE |
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