The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus
| Autor: | Yasuo Tamura, Mitsuo Iinuma, Kin-ya Kubo, Fumihiko Iwaku, Chika Kurata, Yasutoku Kogaya, Naonori Saitoh, Yoko Arakawa, Yukiko Ichihashi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Dorsum Gerontology Aging medicine.medical_specialty Hippocampus Mice Inbred Strains Nerve Tissue Proteins Hippocampal formation Bite Force Neuron loss Dental Occlusion Mice Internal medicine Glial Fibrillary Acidic Protein medicine Animals Process (anatomy) Neurons Masticatory dysfunction Glial fibrillary acidic protein biology Pyramidal Cells Dentate gyrus Endocrinology nervous system Astrocytes Dentate Gyrus biology.protein Anatomy |
| Zdroj: | Okajimas Folia Anatomica Japonica. 85:43-48 |
| ISSN: | 1881-1736 0030-154X |
| DOI: | 10.2535/ofaj.85.43 |
| Popis: | The bite raised condition decreases the number of neurons and increases the amount of glial fibrillary acidic protein in the hippocampus of aged SAMP8 mice. In the present study, we examined whether these effects differ between the dorsal and ventral hippocampus. In bite-raised SAMP8 mice, the number of neurons was significantly lower in the hippocampal CA1 and dentate gyrus (DG) subfields compared to control mice. In the bite raised condition, the number of neurons was significantly lower in both the dorsal and ventral CA3 subfields, and the number of glial fibrillary acidic protein-labeled astrocytes was increased in the CA1, CA3, and DG subfields, compared to control mice. These data suggest that in aged SAMP8 mice, the bite-raised condition enhanced aging processes in both the dorsal and ventral hippocampus. |
| Databáze: | OpenAIRE |
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