Indole - the scent of a healthy 'inner soil'

Autor: Jan Raa, Arnold Berstad, Jørgen Valeur
Rok vydání: 2015
Předmět:
Zdroj: Microbial Ecology in Health and Disease
Microbial Ecology in Health and Disease; Vol 26 (2015)
Microbial Ecology in Health and Disease, Vol 26, Iss 0, Pp 1-5 (2015)
ISSN: 0891-060X
1651-2235
Popis: Tryptophan is an essential amino acid with an indole nucleus. Humans cannot produce this amino acid themselves, but must obtain it through their diet. Much attention is currently paid to the wide physiological and clinical implications of the tryptophan-derived substances, serotonin and kynurenines, generated by human enzymes following the intestinal absorption of tryptophan. However, even before being absorbed, several microbial metabolites of tryptophan are formed, mainly from ‘malabsorbed’ (incompletely digested) proteins within the colon. The normal smell of human faeces is largely due to indole, one of the major metabolites. Recent studies indicate that this foul-smelling substance is also of utmost importance for our health. Keywords: hydrogen peroxide; indole; indoleamine dioxygenase; irritable bowel syndrome; melatonin; tryptophan (Published: 14 August 2015) Citation: Microbial Ecology in Health & Disease 2015, 26 : 27997 - http://dx.doi.org/10.3402/mehd.v26.27997
Databáze: OpenAIRE