Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran
| Autor: | Mahmoud Parian, Fariba Berenji, Zahra Gheisari, Seyed Aliakbar Shamsian, Bibi Razieh Hosseini Farash, Lida Jarahi, Ghodratollah Salehi Sangani, Fatemeh Nazemian |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Article Subject Opportunistic infection 030106 microbiology Infectious and parasitic diseases RC109-216 Microbiology Kidney transplant Organ transplantation 03 medical and health sciences 0302 clinical medicine Virology Internal medicine medicine 030212 general & internal medicine Medical prescription Lophomonas blattarum business.industry medicine.disease Pneumonia Metronidazole Infectious Diseases Sputum Parasitology medicine.symptom business Research Article medicine.drug |
| Zdroj: | Interdisciplinary Perspectives on Infectious Diseases, Vol 2020 (2020) Interdisciplinary Perspectives on Infectious Diseases |
| ISSN: | 1687-7098 1687-708X |
| DOI: | 10.1155/2020/6631224 |
| Popis: | Background. Lophomonas blattarum is a flagellate protozoan which is known as an emerging parasite in the human respiratory system. Organ transplant recipients are considered as immunocompromised patients due to prescription of immunosuppressive drugs. This group of patients is susceptible to opportunistic infection as well as lophomoniasis. This study aims to investigate the prevalence and clinical manifestation of pulmonary infections caused by L. blattarum in kidney transplant recipients. Methods. This is a case-control study including 50 kidney transplant recipients and 50 controls. The sputum samples were collected from 50 kidney transplant recipients with bronchopulmonary infection signs suspected to lophomoniasis admitted in Montaserieh and Imam Reza hospitals, Mashhad, Iran. 50 healthy individuals as the control group were matched for sex and age with case ones. The consent form, checklist, and required information were provided for each patient. All samples were microscopically examined for the flagellated protozoan, L. blattarum, using direct smear. Results. Among 50 kidney transplant recipients suspected to lophomoniasis, L. blattarum was identified in sputum samples of 4 (8%) participants of the case group including one female and three males. None of the samples were positive among the control group. Symptoms in patients of this study were high fever (4 out of 4 patients), cough (3 out of 4 patients), and dyspnea (2 out of 4 patients). Three patients showed a positive response to metronidazole treatment. Conclusion. The results of this study suggest that L. blattarum should be considered as a pathogenic agent in kidney transplant recipients. It is necessary to examine sputum samples in posttransplant pneumonia patients, especially in those resistant to antibacterial therapy. |
| Databáze: | OpenAIRE |
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