AI-Based Quantitative CT Analysis of Temporal Changes According to Disease Severity in COVID-19 Pneumonia
| Autor: | Jale Karakaya, Arzu Topeli, Ahmet Çağkan İnkaya, Figen Başaran Demirkazık, Meltem Gulsun Akpinar, Orhan Macit Ariyurek, Serpil Öcal, Ilim Irmak, Selin Ardali Duzgun, Erhan Akpinar, Gamze Durhan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Coronavirus disease 2019 (COVID-19) Opacity temporal Sensitivity and Specificity Severity of Illness Index Time Thoracic Imaging Young Adult quantitative Disease severity Artificial Intelligence medicine Humans pneumonia Radiology Nuclear Medicine and imaging Lung volumes Clinical severity Lung Aged Retrospective Studies Aged 80 and over Receiver operating characteristic analysis SARS-CoV-2 business.industry Ct analysis COVID-19 Reproducibility of Results Middle Aged medicine.disease Pneumonia Evaluation Studies as Topic Radiographic Image Interpretation Computer-Assisted Female Tomography X-Ray Computed Nuclear medicine business CT |
| Zdroj: | Journal of Computer Assisted Tomography |
| ISSN: | 1532-3145 0363-8715 |
| DOI: | 10.1097/rct.0000000000001224 |
| Popis: | Objective To quantitatively evaluate computed tomography (CT) parameters of coronavirus disease 2019 (COVID-19) pneumonia an artificial intelligence (AI)-based software in different clinical severity groups during the disease course. Methods From March 11 to April 15, 2020, 51 patients (age, 18-84 years; 28 men) diagnosed and hospitalized with COVID-19 pneumonia with a total of 116 CT scans were enrolled in the study. Patients were divided into mild (n = 12), moderate (n = 31), and severe (n = 8) groups based on clinical severity. An AI-based quantitative CT analysis, including lung volume, opacity score, opacity volume, percentage of opacity, and mean lung density, was performed in initial and follow-up CTs obtained at different time points. Receiver operating characteristic analysis was performed to find the diagnostic ability of quantitative CT parameters for discriminating severe from nonsevere pneumonia. Results In baseline assessment, the severe group had significantly higher opacity score, opacity volume, higher percentage of opacity, and higher mean lung density than the moderate group (all P ≤ 0.001). Through consecutive time points, the severe group had a significant decrease in lung volume (P = 0.006), a significant increase in total opacity score (P = 0.003), and percentage of opacity (P = 0.007). A significant increase in total opacity score was also observed for the mild group (P = 0.011). Residual opacities were observed in all groups. The involvement of more than 4 lobes (sensitivity, 100%; specificity, 65.26%), total opacity score greater than 4 (sensitivity, 100%; specificity, 64.21), total opacity volume greater than 337.4 mL (sensitivity, 80.95%; specificity, 84.21%), percentage of opacity greater than 11% (sensitivity, 80.95%; specificity, 88.42%), total high opacity volume greater than 10.5 mL (sensitivity, 95.24%; specificity, 66.32%), percentage of high opacity greater than 0.8% (sensitivity, 85.71%; specificity, 80.00%) and mean lung density HU greater than -705 HU (sensitivity, 57.14%; specificity, 90.53%) were related to severe pneumonia. Conclusions An AI-based quantitative CT analysis is an objective tool in demonstrating disease severity and can also assist the clinician in follow-up by providing information about the disease course and prognosis according to different clinical severity groups. |
| Databáze: | OpenAIRE |
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