Co-expression and clinical utility of Snail and N-cadherin in papillary thyroid carcinoma
Autor: | Ranran Shi, Xiangshan Yang, Jing Zhang |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Snail Metastasis Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Western blot Antigens CD Cell Line Tumor biology.animal Internal medicine parasitic diseases Biomarkers Tumor medicine Humans Thyroid Neoplasms Thyroid cancer Aged biology medicine.diagnostic_test Cadherin Carcinoma fungi General Medicine Middle Aged Cadherins medicine.disease Immunohistochemistry Carcinoma Papillary Gene Expression Regulation Neoplastic 030104 developmental biology Endocrinology Thyroid Cancer Papillary Lymphatic Metastasis 030220 oncology & carcinogenesis Cancer research Female Snail Family Transcription Factors Lymph |
Zdroj: | Tumor Biology. 37:413-417 |
ISSN: | 1423-0380 1010-4283 |
Popis: | Papillary thyroid carcinoma is one of the most common subtypes of thyroid cancer and portends a good prognosis. N-cadherin (neural cadherin) is a member of the classical cadherin family and is often overexpressed in many types of cancers. Snail, a kind of zinc finger protein, is a transcriptional repressor which has been intensively studied in mammals. We investigate the immunohistochemical expression of Snail and N-cadherin in papillary thyroid carcinoma tissues and cells and then discuss the clinical value of Snail and N-cadherin expression. Immunohistochemical technique was performed to detect Snail and N-cadherin in 60 cases of papillary thyroid carcinoma and analyzed the relationship between the expression of Snail, N-cadherin, and clinicopathological indicators. Western blot was used to investigate the constitutive and inducible expression of Snail and N-cadherin. In our study, the expression rate of Snail and N-cadherin was 85.0 % (51/60) and 78.3 % (47/60), respectively, in papillary thyroid carcinoma. The expression rate of Snail and N-cadherin in thyroid papillary carcinoma with metastatic lymph nodes was 93.3 and 86.7 %, respectively, while in papillary thyroid carcinoma tissue without lymph node metastasis, the expression rate was 60.0 and 53.3 %, respectively. The positive correlation of Snail and N-cadherin was observed (r = 0.721, p |
Databáze: | OpenAIRE |
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