The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice
| Autor: | Ricard Cervera, Gabriela Riemekasten, Mauro Galeazzi, Frédéric Houssiau, Pier Luigi Meroni, Reinhard E. Voll, Chiara Tani, David D'Cruz, Matthias Schneider, V. Rios, G. M. Steup-Beekman, D. De La Fuente, E. Norkuviene, Martin Aringer, Walter Bencivelli, Fausto Salaffi, Magdalena Szmyrka-Kaczmarek, Y Shoenfeld, Marta Mosca, Andrea Doria, Munther A. Khamashta, Twj Huizinga, Paola Tomietto, Carlomaurizio Montecucco, Cátia Duarte, Angela Tincani, Marcello Govoni, Maura Couto, Athanasios G. Tzioufas, Luís Inês, Dimitrios T. Boumpas, Stefano Bombardieri, Fabrizio Conti |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Delphi Technique neuropsychiatric lupus Neuropsychiatric involvement Clinical practice Systemic Lupus Erythematosus Rheumatology Medizinische Fakultät Internal medicine Surveys and Questionnaires Area under curve medicine Humans Lupus vasculitis Routine clinical practice ddc:610 Clinical practice neuropsychiatric lupus questionnaire screening systemic lupus erythematosus systemic-lupus-erythematosus migraine-act questionnaire response inventory ansri central-nervous-system to-day impact inception cohort psychometric evaluation cognitive impairment multiple-sclerosis seizure severity Clinical practice neuropsychiatric lupus questionnaire screening systemic lupus erythematosus clinical practice questionnaire screening systemic lupus erythematosus business.industry Lupus Vasculitis Central Nervous System medicine.disease Clinical Practice ROC Curve Area Under Curve Physical therapy business |
| Zdroj: | Lupus, 20(5), 485-492 |
| Popis: | Aim: The creation of a physician-administered questionnaire to screen patients with Systemic Lupus Erythematosus (SLE) for the presence of symptoms suggestive of neuropsychiatric involvement (NPSLE). Methods: The development of the questionnaire followed three phases. First, a list of manifestations was prepared based on the ACR case definitions for NPSLE. A first questionnaire was constructed including 119 items. To reduce their number, a Delphi analysis was carried out and a second questionnaire with 62 questions was developed. This questionnaire was administered to 139 patients with SLE (58 with NPSLE: 29 active, 29 inactive; and 81 without NPSLE: 39 active, 42 inactive). Questions relevant to the screening of patients were selected on the basis of the receiver operating characteristic (ROC) curve analysis. Results: Twenty-seven questions concerning central nervous system and psychiatric manifestations were found to be relevant; the remaining could be eliminated without significantly affecting AUC. The area under the ROC curve (AUC) was 0.69 (95% CI 0.61–0.78). A score above 17 was considered as suggestive of the presence of NPSLE with a sensitivity of 92.9% (95% CI 85.1–97.3 %) and specificity of 25.4% (95% CI 14.7–39.00 %). Conclusions: This questionnaire could represent a ‘core set’ of questions that could help in clinical practice to identify patients with neuropsychiatric symptoms requiring further evaluation. |
| Databáze: | OpenAIRE |
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