Klotho-HIV and Oxidative Stress: The Role of Klotho in Cardiovascular Disease Under HIV Infection—A Review
| Autor: | María Elena Gutiérrez Pérez, Alberto Alejandro Miranda Pérez, Arguiñe Ivonne Urraza Robledo, Dealmy Delgadillo Guzmán, Pablo Ruiz Flores, Francisco Carlos López Márquez |
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| Rok vydání: | 2020 |
| Předmět: |
Cirrhosis
Heart disease Human immunodeficiency virus (HIV) HIV Infections Disease Biology urologic and male genital diseases medicine.disease_cause Antiretroviral Therapy Highly Active Genetics medicine Animals Humans Klotho Proteins Molecular Biology Klotho Glucuronidase chemistry.chemical_classification Reactive oxygen species Cell Biology General Medicine medicine.disease Oxidative Stress chemistry Cardiovascular Diseases Immunology Oxidative stress Kidney disease |
| Zdroj: | DNA and Cell Biology. 39:1478-1485 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2020.5444 |
| Popis: | Combined antiretroviral therapy has improved quality and life expectancy of people living with human immunodeficiency virus (HIV). However, this therapy increases oxidative stress (OS), which in turn causes alterations in lipid and carbon metabolism, kidney disease, liver cirrhosis, and increased risk of cardiovascular disease. The Klotho gene has been implicated in cardiovascular risk increase. Klotho protein expression at X level decreases the risk of heart disease. HIV-positive people usually present low plasma levels of Klotho; thus, contributing to some extent to an increase in cardiovascular risk for these types of patients, mostly by favoring atherosclerosis. Therefore, our aim is to provide an overview of the effect of OS on Klotho protein and its consequent cardiometabolic alterations in HIV-positive patients on antiretroviral therapy. |
| Databáze: | OpenAIRE |
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