A Comprehensive Grading System for a Magnetic Sentinel Lymph Node Biopsy Procedure in Head and Neck Cancer Patients
| Autor: | Eliane R. Nieuwenhuis, Barry Kolenaar, Jurrit J. Hof, Joop van Baarlen, Alexander J. M. van Bemmel, Anke Christenhusz, Tom W. J. Scheenen, Bernard ten Haken, Remco de Bree, Lejla Alic |
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| Přispěvatelé: | TechMed Centre, Magnetic Detection and Imaging |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
tracer distribution
Cancer Research UT-Gold-D magnetic tracer Histopathology Lymphography superparamagnetic iron oxide (SPIO) Neoplasms. Tumors. Oncology. Including cancer and carcinogens oral cancer sentinel lymph node MRI lymphography histopathology grading system All institutes and research themes of the Radboud University Medical Center Oncology Grading system Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] RC254-282 |
| Zdroj: | Cancers; Volume 14; Issue 3; Pages: 678 Cancers, Vol 14, Iss 678, p 678 (2022) Cancers, 14, 3 Cancers, 14(3):678. MDPI Cancers, 14 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14030678 |
| Popis: | A magnetic sentinel lymph node biopsy ((SLN)B) procedure has recently been shown feasible in oral cancer patients. However, a grading system is absent for proper identification and classification, and thus for clinical reporting. Based on data from eight complete magnetic SLNB procedures, we propose a provisional grading system. This grading system includes: (1) a qualitative five-point grading scale for MRI evaluation to describe iron uptake by LNs; (2) an ex vivo count of resected SLN with a magnetic probe to quantify iron amount; and (3) a qualitative five-point grading scale for histopathologic examination of excised magnetic SLNs. Most SLNs with iron uptake were identified and detected in level II. In this level, most variance in grading was seen for MRI and histopathology; MRI and medullar sinus were especially highly graded, and cortical sinus was mainly low graded. On average 82 ± 58 µg iron accumulated in harvested SLNs, and there were no significant differences in injected tracer dose (22.4 mg or 11.2 mg iron). In conclusion, a first step was taken in defining a comprehensive grading system to gain more insight into the lymphatic draining system during a magnetic SLNB procedure. |
| Databáze: | OpenAIRE |
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