Effect of Pirprofen on Protein Binding of Warfarin and Tolbutamide in Human Plasma
| Autor: | Richard C. Luders, Dolly Chao |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Drug
Phenylpropionates Chemistry Tolbutamide media_common.quotation_subject Anti-Inflammatory Agents Temperature Warfarin Pharmaceutical Science Plasma protein binding In Vitro Techniques Pharmacology Blood proteins In vitro Pirprofen medicine Humans Pyrroles Dosing Protein Binding medicine.drug media_common |
| Zdroj: | Journal of Pharmaceutical Sciences. 70:1370-1371 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600701221 |
| Popis: | The extent of warfarin and tolbutamide binding to plasma proteins was determined with and without pirprofen by an ultrafiltration procedure employing 14 C‐labeled drugs. Results from in vitro studies at 37° showed that the degree of binding amounted to 97.8% for warfarin and 95.6% for tolbutamide. The binding characteristics of these drugs were not altered when plasma containing either warfarin or tolbutamide at concentrations equivalent to those expected normally after therapeutic dosing were concomitantly spiked with therapeutic amounts of pirprofen. Consequently, potentiation resulting from drug displacement would not be anticipated in humans when pirprofen is administered along with warfarin or tolbutamide. |
| Databáze: | OpenAIRE |
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