Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer
| Autor: | Anders Larsson, Linda Johansson, Karin Björkegren, Åke Berglund, Per Byström |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Colorectal cancer medicine.medical_treatment colorectal cancer Antineoplastic Agents folate Gastroenterology Cobalamin Cohort Studies chemistry.chemical_compound Folic Acid Internal medicine hemic and lymphatic diseases Epidemiology medicine polycyclic compounds Chemotherapy Humans cobalamin Aged business.industry Case-control study nutritional and metabolic diseases General Medicine homocysteine Middle Aged medicine.disease Vitamin B 12 chemistry Case-Control Studies Cohort Immunology Original Article Female business Colorectal Neoplasms Cohort study |
| Zdroj: | Upsala Journal of Medical Sciences |
| ISSN: | 2000-1967 0300-9734 |
| Popis: | Background There are conflicting results on the role of cobalamin and folate for epidemiology and carcinogenesis in colorectal cancer patients and the need of supplementation for prevention of chemotherapy toxicity. Patients and methods Serum cobalamin, folate, and homocysteine were analysed before and during the treatment of 93 patients with advanced colorectal cancer (ACRC) with first-line chemotherapy treatment. This cohort was compared with a healthy control group of 224 individuals. Results Patients with ACRC had similar cobalamin, folate, and homocysteine values as the healthy control group. There were no correlations between serum cobalamin, folate, and homocysteine values and objective response. There were no correlations to anaemia or other severe toxicity for cobalamin and homocysteine. A total of 12 patients had folate deficiency, and 10 of those suffered from severe toxicity (grade 3 or more). All patients had markedly increased folate values after 2 months of treatment. Folate and homocysteine did not predict patient outcome; however, patients with subclinically low cobalamin values ( |
| Databáze: | OpenAIRE |
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