Gastrointestinal uptake of FDG after N-butylscopolamine or omeprazole treatment in the rat
| Autor: | Kunihiro Nakada, Masahiro Asaka, Songji Zhao, Fumiyasu Yamamoto, Nagara Tamaki, Masayuki Satoh |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Gastroenterology Rats Sprague-Dawley Cecum Fluorodeoxyglucose F18 Internal medicine Butylscopolammonium Bromide medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging Esophagus Radionuclide Imaging Omeprazole Fasting state medicine.diagnostic_test business.industry Fdg uptake Stomach General Medicine Small intestine Rats Gastrointestinal Tract Drug Combinations medicine.anatomical_structure Organ Specificity Positron emission tomography Radiopharmaceuticals business medicine.drug |
| Zdroj: | Annals of Nuclear Medicine. 18:637-640 |
| ISSN: | 1864-6433 0914-7187 |
| Popis: | Objective: Gastrointestinal (GI) uptake of 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) is frequently observed in whole-body positron emission tomography (PET) images. Such physiological uptake may interfere with accurate interpretation. The aim of the present study was to determine whether physiological gastrointestinal FDG uptake can be decreased by means of an antiperistaltic agent,N-butylscopolamine, or a gastric secretion inhibitor, omeprazole.Methods: Sprague-Dawley rats were divided into three groups: omeprazole-treated (n = 6),N-butylscopolamine-treated (n = 7), and control group (n = 6). The rats in the omeprazole-treated group were administered omeprazole (1.0 mg/kg) intravenously 45 minutes before FDG injection. The rats in theN-butylscopolamine-treated group were administered N-butylscopolamine ( 1.0 mg/kg) intramuscularly 10 minutes before FDG injection. Sixty minutes after FDG injection under overnight fasting state, the gastrointestinal tissues were excised and weighed to determine the radioactivity of18F using a gamma counter.Results: The mean values of FDG uptake in the esophagus, stomach, small intestine, cecum and colon of the N-butylscopolamine-treated group vs. the omeprazole-treated group were 148% vs. 162%, 109% vs. 113%, 113% vs. 88%, 102% vs. 85%, 105% vs. 70% of the control group, respectively. There were no statistical differences in FDG uptake rate in the esophagus, stomach, or cecum among the three groups. FDG uptake rates in the small intestine and colon of the omeprazole-treated group were significantly lower than those in the control group.Conclusion: Physiological FDG uptake in the GI tract was not decreased by the administration ofN-butylscopolamine. Omeprazole was effective in decreasing FDG uptake in the small intestine and colon. Omeprazole has a potential to decrease FDG uptake rate in a limited part of the GI tract. |
| Databáze: | OpenAIRE |
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