Effects of colchicine on central and peripheral nerve terminals of the locustSchistocerca gregaria
| Autor: | Michael P. Osborne, R. A. Nicholson, J. M. Pocock |
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| Rok vydání: | 1990 |
| Předmět: |
Central Nervous System
Nervous system animal structures Histology Grasshoppers Synaptic vesicle chemistry.chemical_compound medicine Animals Colchicine Peripheral Nerves Nerve Endings biology General Neuroscience Cell Biology Anatomy biology.organism_classification Cell biology medicine.anatomical_structure chemistry Peripheral nervous system Ultrastructure Axoplasmic transport Schistocerca Free nerve ending Synaptosomes |
| Zdroj: | Journal of Neurocytology. 19:574-583 |
| ISSN: | 1573-7381 0300-4864 |
| Popis: | The treatment of locusts (Schistocerca gregaria) with colchicine leads to various changes in the ultrastructure of both central and peripheral nerve terminals. These changes include a marked reduction in synaptic vesicle density, which is further enhanced following stimulation. There are also increased numbers of coated pits and membraneous cisternae together with enlarged terminal areas and disruption of mitochondrial ultrastructure. The capacity of isolated central nerve terminals (synaptosomes) to take up the radiolabelled transmitter precursor [3H]-choline is enhanced following in vivo treatment of locusts with colchicine, whilst in vitro treatment leads to a reduction in choline uptake. The results are discussed with regard to the postulated effects of colchicine on axoplasmic transport. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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