Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena
| Autor: | Miguel Etchart, Xabier de Aretxabala U, Ximena Torrens, Gerardo Fasce P, Marcela Planzer D, Jorge Maira S, Ricardo Santander D, José Ignacio Fernández F, Alex Navarro R, Iván Gallegos, Ivette Reydet, Fernando Gómez L, Samuel Sabah T |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
biology Pepsinogens business.industry Gastritis atrophic Stomach neoplasms Intestinal metaplasia Cancer General Medicine Cancer detection medicine.disease digestive system Gastroenterology digestive system diseases Pepsin Internal medicine Metaplasia medicine Pepsinogen II biology.protein lipids (amino acids peptides and proteins) Gastritis medicine.symptom Prospective cohort study business |
| Zdroj: | Revista médica de Chile v.135 n.12 2007 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Background: Gastric cancer has a direct relation with chronic atrophic gastritis (AG) and intestinal metaplasia (IM), considered as preneoplastic lesions. Determination of serum pepsinogen llevéis (PGI) and pepsinogen I / pepsinogen II ratio (PGI/PGII) can detect this conditions; achieving 70-90% of gastric cancer detection in early stages. Aim: To determine the cut-off values for serum PGI and PGI/PGII in Chilean subjects, for the detection of gastric preneoplastic lesions, establishing their sensitivity, specificity, positive (PPV) and negative (NPV) predictive values. Patients and Methods: Prospective study of patients subjected to upper gastrointestinal endoscopy and determination of serum pepsinogen levels. The presence and severity of preneoplastic lesions were compared with serum levels of PGI and PGI/PGII. Results: A total of 56 men and 44 women were studied, with a mean age of 43 (14-77) years. There was a significant association (p , specificity =92%>, PPV =60%>, NPV =95%) and 36 ng/ml for PGI (sensitivity =62%o specificity =64%o, PPV =20%o, NPV =91%), for detection of moderate to severe AG. No patient with normal mucosa had a PGI , PPV of 65%o, and NPV of 97%o. Conclusions: We confirmed a strict relation ofPGIand PGI/PGIIwith the presence of preneoplastic gastric lesions in Chilean patients |
| Databáze: | OpenAIRE |
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