Biodegradable p(DLLA-?-CL) nerve guides versus autologous nerve grafts: Electromyographic and video analysis
| Autor: | Marcel F. Meek, John F. A. van der Werff, Albert Gramsbergen, J.-P. A. Nicolai |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Time Factors Physiology Polyesters Abnormal EMG Video Recording Biodegradable copolymers Biocompatible Materials Walking Electromyography Motor Activity Transplantation Autologous Nerve guide Functional Laterality Cellular and Molecular Neuroscience Gastrocnemius muscle Gait (human) Physiology (medical) medicine Animals Rats Wistar Muscle Skeletal Gait medicine.diagnostic_test business.industry Anatomy Sciatic Nerve Rats Biodegradation Environmental medicine.anatomical_structure Peripheral nervous system Neurology (clinical) Sciatic nerve business |
| Zdroj: | Muscle & Nerve. 24:753-759 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/mus.1066 |
| Popis: | The aim of this study was to evaluate the functional effects of bridging a gap in the sciatic nerve of the rat with either a biodegradable copolymer of DL-lactide and epsilon-caprolactone [p(DLLA-epsilon-CL)] nerve guide or an autologous nerve graft. Electromyograms (EMGs) of the gastrocnemius (GC) and tibialis anterior (TA) muscles were recorded 3.5 and 5 months after bridging the nerve gaps. Furthermore, the rats' gait was recorded on video and the quality of the gait was analyzed. EMG patterns of the contralateral nonoperated side were essentially normal. The EMG patterns on the operated side were irregular in all animals, but the quality of gait was better in the nerve guide group. We conclude that the surgical technique (nerve guide or nerve graft) does not influence the occurrence of abnormal EMG patterns, but gait improves to a greater extent when the nerve gap is bridged by a nerve guide. |
| Databáze: | OpenAIRE |
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