Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory
| Autor: | Sarah A. Jablonski, Robyn M. Amos-Kroohs, Anna C. Barnes, Michael T. Williams, Arnold Gutierrez, Charles V. Vorhees |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Serotonin medicine.medical_specialty Physiology Dopamine Cognitive Neuroscience Hippocampus Morris water navigation task Reversal Learning Motor Activity Nucleus accumbens Hippocampal formation Biochemistry Nucleus Accumbens Body Temperature Methamphetamine Rats Sprague-Dawley Norepinephrine 03 medical and health sciences 0302 clinical medicine Internal medicine Glial Fibrillary Acidic Protein medicine Animals Maze Learning Swimming Spatial Memory Chemistry Neurotoxicity Cell Biology General Medicine medicine.disease Housing Animal Neostriatum 030104 developmental biology Endocrinology Monoamine neurotransmitter nervous system Corticosterone Neuroscience Stress Psychological 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS Chemical Neuroscience. 8:1479-1489 |
| ISSN: | 1948-7193 |
| Popis: | Severe stress potentiates methamphetamine (MA) neurotoxicity. However, whether moderate stress increases or decreases the neurotoxic effects of MA is unknown. We assessed the effects of MA (4 × 10 mg/kg at 2 h intervals) in combination with prior barren-cage housing in adult male Sprague-Dawley rats on monoamines and glial fibrillary acid protein (GFAP) in one cohort and spatial learning and memory in the Morris water maze in another cohort. MA reduced dopamine (DA) and serotonin (5-HT) in the neostriatum and nucleus accumbens, 5-HT in the hippocampus, and increased GFAP in neostriatum and nucleus accumbens compared with saline controls. In neostriatum, barren-cage housing protected against MA-induced increases in GFAP, but it did not prevent DA and 5-HT reductions, although it did increase hippocampal norepinephrine. MA impaired spatial learning during acquisition, reversal, and shift phases and impaired reference memory on reversal and shift probe trials. Barren-cage housing enhanced performance during acquisition but not during reversal or shift or on probe trials. The data indicate that prior barren-cage housing moderates MA-induced neostriatal astrogliosis and initial spatial learning, but has no protective effect when the platform is smaller and relocated and therefore requires cognitive flexibility in relearning. |
| Databáze: | OpenAIRE |
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