Intraocular pressure control and visual field changes in primary angle closure disease: the CUHK PACG Longitudinal (CUPAL) study
| Autor: | Clement C Y Tham, Shaoying Tan, Carol Y. Cheung, Sophia Ling Li, Noel C Y Chan, Poemen Pui Man Chan, Xiaofei Man |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Time Factors genetic structures Glaucoma Trabeculectomy Independent predictor Tonometry Ocular Cellular and Molecular Neuroscience Categorical analysis Ophthalmology medicine Humans In patient Prospective Studies Intraocular Pressure Aged business.industry medicine.disease eye diseases Sensory Systems Visual field Absolute deviation Disease Progression Female sense organs Visual Fields Glaucoma Angle-Closure business Follow-Up Studies |
| Zdroj: | British Journal of Ophthalmology. 104:629-635 |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2019-314322 |
| Popis: | PurposeTo determine the relationship of intraocular pressure (IOP) control with subsequent visual field (VF) deterioration in patients with primary angle closure disease (PACD).Methods419 PACD eyes from 240 Chinese patients were included. Mean IOP and IOP fluctuation were calculated as the average and SD divided by mean IOP, respectively, of all the IOP measured in the initial 18 months for assessment of IOP control. The relationship between IOP control and subsequent VF parameters over time was examined using linear mixed models. VF deterioration was defined as IOP control associated with decreased VF parameters over time with a p value ResultsGreater IOP fluctuation was significantly associated with VF deterioration, independent of mean IOP (mean deviation (MD) β=−6.36, p=0.03; VF index β=−16.41, p=0.04; and cataract-adjusted MD β=−6.96, p=0.02). In the categorical analysis, those with both high-threshold mean IOP and high-threshold IOP fluctuation had the most rapid VF deterioration, compared with eyes with low-threshold IOP fluctuation (pConclusionsIOP fluctuation was a significant and independent predictor for subsequent VF deterioration in eyes with PACD. |
| Databáze: | OpenAIRE |
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