Influence of post-stroke fatigue on reaction times and corticospinal excitability during movement preparation

Autor: Annapoorna Kuppuswamy, William De Doncker, Katlyn E. Brown
Rok vydání: 2020
Předmět:
Male
RT70
70% Reaction Time
medicine.medical_treatment
Pyramidal Tracts
RT
reaction time
Stimulation
SDMT
symbol digit modalities test
FDI
first dorsal interosseous
0302 clinical medicine
NHPT
nine-hole peg test
Stroke
Fatigue
05 social sciences
Motor Cortex
RMT
resting motor threshold
Middle Aged
RT30
30% Reaction time
Transcranial Magnetic Stimulation
Sensory Systems
Neurology
IS
imperative stimulus
Facilitation
Female
medicine.medical_specialty
Sensory processing
Movement
050105 experimental psychology
Article
03 medical and health sciences
Physical medicine and rehabilitation
WS
warning stimulus
Physiology (medical)
HADS
hospital anxiety and depression scale
Motor system
WP
warning period
RT50
50% Reaction time
medicine
Reaction Time
Humans
0501 psychology and cognitive sciences
Muscle
Skeletal
PSF
post-stroke fatigue
Movement preparation
Aged
M1
primary motor cortex
Sensory attenuation
business.industry
Electromyography
TMS
transcranial magnetic stimulation
medicine.disease
Evoked Potentials
Motor
Transcranial magnetic stimulation
Cross-Sectional Studies
Acoustic Stimulation
TMS
Post stroke
Neurology (clinical)
business
FSS-7
fatigue severity scale
EMG
electromyography
030217 neurology & neurosurgery
Zdroj: Clinical Neurophysiology
ISSN: 1872-8952
Popis: Highlights • Higher the fatigue, lesser the inhibition in movement preparation in stroke survivors. • Higher the fatigue, lesser the pre-movement facilitation and slower the reaction times. • Poor excitability modulation supports sensory attenuation model of fatigue.
Objectives Reduced corticospinal excitability at rest is associated with post-stroke fatigue (PSF). However, it is not known if corticospinal excitability prior to a movement is also altered in fatigue which may then influence subsequent behaviour. We hypothesized that the levels of PSF can be explained by differences in modulation of corticospinal excitability during movement preparation. Methods 73 stroke survivors performed an auditory reaction time task. Corticospinal excitability was measured using transcranial magnetic stimulation. Fatigue was quantified using the fatigue severity scale. The effect of time and fatigue on corticospinal excitability and reaction time was analysed using a mixed effects model. Results Those with greater levels of PSF showed reduced suppression of corticospinal excitability during movement preparation and increased facilitation immediately prior to movement onset (β = −0.0066, t = −2.22, p = 0.0263). Greater the fatigue, slower the reaction times the closer the stimulation time to movement onset (β = 0.0024, t = 2.47, p = 0.0159). Conclusions Lack of pre-movement modulation of corticospinal excitability in high fatigue may indicate poor sensory processing supporting the sensory attenuation model of fatigue. Significance We take a systems-based approach and investigate the motor system and its role in pathological fatigue allowing us to move towards gaining a mechanistic understanding of chronic pathological fatigue.
Databáze: OpenAIRE
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