New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia
| Autor: | Shigehito Mori, Kazuya Kawano, Masao Kurosumi, Tsukasa Hirashima, Yuichi Saitoh, Takashi Natori |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism T-Lymphocytes Diabetes Mellitus Experimental Pathogenesis Islets of Langerhans Inbred strain Polyuria Internal medicine Diabetes mellitus Lymphopenia Internal Medicine medicine Animals Insulin business.industry Incidence Rats Inbred Strains DNA Ketones medicine.disease Blood Cell Count Rats Disease Models Animal Endocrinology Polyphagia Diabetes Mellitus Type 1 Female Lymphocytopenia medicine.symptom business Insulitis Polydipsia Polymorphism Restriction Fragment Length |
| Zdroj: | Diabetes. 40(11) |
| ISSN: | 0012-1797 |
| Popis: | Spontaneously diabetic rats with remarkable polyuria, polyphagia, and polydipsia werediscovered in 1983 in an outbred colony of Long-Evans rats purchased from Charles River Canada in 1982. They have since been maintained at the Tokushima Research Institute (OtsukaPharmaceutical, Tokushima, Japan). A strain of rats (Long-Evans Tokushima Lean [LETL]) with diabetes was bred from these rats. The characteristic features of the disease in LETL rats are 1) sudden onset of polyuria, polyphagia, hyperglycemia, andweight loss; 2) no sex differences in the rate of onset or severity; 3) lymphocyte infiltration into islets followed by destruction of β-cells and disappearance of lymphocytes at the onset of diabetes; 4) no significant T lymphopenia; 5) lymphocyte infiltration into the salivary glands and lacrimal glands; and 6) at least two recessive genes involved in the pathogenesis of insulitis, one of which is closely linked with RT1u. These characteristics closely resemble those of human insulin-dependent diabetes mellitus (IDDM). Results suggest that the LETL rat is a useful animal model for analysisof genetic and immunologic factors relating to the pathogenesis of human IDDM. |
| Databáze: | OpenAIRE |
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