Vitamin D deficiency and placental calcification in low-risk obstetric population: are they related?
| Autor: | Yasemin Tasci, Rahime Bedir Findik, Jale Karakaya, Vildan Fidanci, Yeksin Helvacioglu, Ali Özgür Ersoy |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Placenta Diseases Population 030209 endocrinology & metabolism Umbilical cord Gastroenterology vitamin D deficiency Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Placenta medicine Vitamin D and neurology Humans Prospective Studies education Calcifediol education.field_of_study 030219 obstetrics & reproductive medicine business.industry Calcinosis Obstetrics and Gynecology Fetal Blood Vitamin D Deficiency medicine.disease medicine.anatomical_structure Case-Control Studies Cord blood Pediatrics Perinatology and Child Health Female business Calcification |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 29:3189-3192 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | We aimed to evaluate the relationship between placental calcification and maternal and cord blood 25-hydroxyvitamin-D3 [25(OH)D] and calcium concentrations in low-risk obstetric population at term and their consequences.Sixty non-complicated pregnant women at term admitted to maternity clinic were included in this prospective case-control study and classified into one of two groups according to grade of placental calcification by defined the Grannum classification: Group 1 (n=30), with Grade 3 placenta and Group 2 (n=30), the control group, no placental calcification noted. Baseline characteristics, maternal serum and umbilical cord 25(OH)D and calcium levels were compared between groups.The mean age of subjects was 26.4 ± 5.7 years. The mean serum 25(OH)D concentration of women (n=60) was 9.3 ± 3.4 (range 5.59-15.48) ng/mL. The prevalence of vitamin D deficiency [25(OH)D 20 ng/mL] was 100%. Maternal serum and cord blood calcium levels were significantly higher in Group 1 (p=0.036; p=0.037, respectively). In Group 2, maternal serum and cord blood 25(OH)D levels were higher than Group 1 (11.35 ± 6.54 and 10.22 ± 3.59 versus 9.6 ± 4.2 and 9.07 ± 2.43 ng/mL); but the difference is not statistically significant.Higher maternal calcium and lower 25(OH)D levels detected in patients with Grade 3 placental calcification indicated the importance of placenta on vitamin D regulation. |
| Databáze: | OpenAIRE |
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