Anticalcification Potential of POSS-PEG Hybrid Hydrogel as a Scaffold Material for the Development of Synthetic Heart Valve Leaflets
| Autor: | Feiyi Wang, Renqi Guo, Siju Liu, Ying Zhou, Nianguo Dong, Junqi Nie, Jiawei Shi, Guichun Yang, Cuifen Lu, Chuang Li |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Scaffold Materials science Biocompatibility Biomedical Engineering Biocompatible Materials law.invention Polyethylene Glycols Biomaterials Rats Sprague-Dawley law Artificial heart PEG ratio Materials Testing medicine Animals Organosilicon Compounds Heart valve Particle Size Molecular Structure Tissue Scaffolds Biochemistry (medical) Hydrogels General Chemistry Rats medicine.anatomical_structure Scaffold material Heart Valve Prosthesis Biomedical engineering |
| Zdroj: | ACS applied bio materials. 4(3) |
| ISSN: | 2576-6422 |
| Popis: | Calcification of bioprosthetics is a primary challenge in the field of artificial heart valves and a main reason for biological heart valve prostheses failure. Recent advances in nanomaterial science have promoted the development of polymers with advantageous properties that are likely suitable for artificial heart valves. In this work, we developed a nanocomposite polymeric biomaterial POSS-PEG (polyhedral oligomeric silsesquioxane-polyethylene glycol) hybrid hydrogel, which not only has improved mechanical and surface properties but also excellent biocompatibility. The results of atomic force microscopy and in vivo animal experiments indicated that the content of POSS in the PEG matrix plays an important role on the surface and contributes to its biological properties, compared to the decellularized porcine aortic valve scaffold. Additionally, this modification leads to enhanced protection of the hydrogel from thrombosis. Furthermore, the introduction of POSS nanoparticles also gives the hydrogel a better calcification resistance efficacy, which was confirmed through in vitro tests and animal experiments. These findings indicate that POSS-PEG hybrid hydrogel is a potential material for functional heart valve prosthetics, and the use of POSS nanocomposites in artificial valves may offer potential long-term performance and durability advantages. |
| Databáze: | OpenAIRE |
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