Diagnostic value of PCA3, TMPRSS2:ERG and prostatic specific antigen derivatives in the detection of prostate cancer
| Autor: | A. A. Musaelyan, V. D. Nazarov, S. V. Lapin, A. G. Boriskin, S. A. Reva, D. G. Lebedev, V. D. Yakovlev, D. A. Viktorov, A. N. Toropovskiy, V. L. Emanuel, S. Kh. Al-Shukri, S. B. Petrov |
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| Rok vydání: | 2020 |
| Předmět: |
prostate cancer early detection
PCA3 medicine.medical_specialty Urology prostatic specific antigen genetic marker of prostate cancer psa derivatives Urine urologic and male genital diseases TMPRSS2 Prostate cancer prostate health index Prostate Positive predicative value Medicine Radiology Nuclear Medicine and imaging business.industry pca3 prostate cancer medicine.disease medicine.anatomical_structure Oncology Fusion transcript Nephrology tmprss2:erg Surgery business Erg |
| Zdroj: | Onkourologiâ, Vol 16, Iss 2, Pp 65-73 (2020) |
| ISSN: | 1996-1812 1726-9776 |
| DOI: | 10.17650/1726-9776-2020-16-2-65-73 |
| Popis: | Background. Prostate cancer (PCa) is one of the most common malignancy in men. A traditional marker in the laboratory diagnosis ofPCa is the prostatic specific antigen (PSA). However, the low specificity of this marker leads to a large number of unnecessary biopsies. The emergence of various modifications of PSA and tumor-specific genetic markers such as PCA3 and TMPRSS2ERG, have improved the diagnosis of PCa.Objective. Investigation of the diagnostic significance of molecular genetic markers, PCA3 and TMPRSS2:ERG, and their comparison with markers based on PSA isoforms: free/total PSA ratio (%fPSA) and prostate health index (PHI).Materials and methods. The study included 58 men with suspected PCa. All patients were defined PCA3 score and the presence of TMPRSS2:ERG fusion transcript in the urine sediment. Also, PHI and %fPSA were determined in 48 and 51 men, respectively.Results. The area under the ROC-curve regardless of the value of PSA was higher for PCA3 score (0.773, p 95 % PCA3 score had the highest specificity, positive and negative predictive values in men, regardless of the level of PSA: 65.22, 80.95, and 93.75 %, respectively. In men with PSA level of 2—10 ng/ml the area under the ROC-curve for PCA3, %fPSA and PHI was 0.776 (p = 0.001), 0.629 (p = 0.144) and 0.729 (p = 0.009), respectively. At high sensitivity (>95 %) characteristics of the diagnostic test PCA3 in men with a PSA level of 2—10 ng/ml also also exceeded those for PHIand %>fPSA. The negative predictive valuefor PCA3score in this group ofmen was 100 %. The sensitivity ofdetection ofthe TMPRSS2:ERG fusion transcript in urine was 37.14 %, specificity 86.96 %, and the positive predictive value was 81.25 %.Conclusion. The use ofthe PCA3 score in combination with the detection of TMPRSS2:ERG fusion will improve the assessment of PCa risk in men with PSA levels between 2 and 10ng/ml (the “grey zone”). |
| Databáze: | OpenAIRE |
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