Preventive Effect of Probiotics on Ventilator-Associated Pneumonia: A Meta-analysis of 2428 Patients
| Autor: | Futai Shang, Xiangcheng Zhang, Ting Ji, Xingxing Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Incidence Probiotics Ventilator-associated pneumonia Pneumonia Ventilator-Associated 030208 emergency & critical care medicine medicine.disease 03 medical and health sciences On ventilator Pneumonia 0302 clinical medicine 030228 respiratory system Meta-analysis medicine Humans Pharmacology (medical) Intensive care medicine business |
| Zdroj: | Annals of Pharmacotherapy. 55:949-962 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1177/1060028020983021 |
| Popis: | Background: Researchers had contradictory conclusions about the role of probiotics in preventing ventilator-associated pneumonia (VAP), which has led to the controversial use of probiotics in mechanically ventilated patients. Objective: To explore the efficacy and safety of probiotics in preventing VAP. Methods: A literature search was conducted in 7 medical databases. Two investigators assessed literature quality independently and collected data. The primary outcome was the incidence of VAP. Secondary outcomes included 16 measures. Sensitivity analysis and subgroup and meta-regression analyses were performed to analyze the source of heterogeneity. P values 2 Results: A total of 20 randomized controlled studies with a total of 2428 patients were analyzed. Pooled results showed positive effects of probiotics on the reduction of VAP incidence (risk ratio [RR] = 0.672; P < 0.001; I2 = 11.3%), length of ICU stay (WMD = −1.417; P = 0.012; I2 = 90.7%), oropharyngeal (RR = 0.866; P = 0.031; I2 = 12.4%) and gastric (RR = 0.645; P < 0.001; I2 = 30.2%) colonization. Conclusions and Relevance: Probiotics can reduce the incidence of VAP and reduce oropharyngeal and gastric bacterial colonization. The results also suggest that probiotics do not cause adverse effects. |
| Databáze: | OpenAIRE |
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