Hypo-β-Lipoproteinaemia Associated with Auto-Antibodies Against β-Lipoproteins
| Autor: | Eva Schlumpf, G. Noseda, Andreas Morell, Walter F. Riesen |
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| Rok vydání: | 1972 |
| Předmět: |
Adult
Immunodiffusion medicine.medical_specialty Lipoproteins Clinical Biochemistry Plasma protein binding Igg gammopathy Biochemistry Immunoglobulin G Arthritis Rheumatoid Hypoproteinemia Internal medicine medicine Humans Autoantibodies biology Chemistry Autoantibody General Medicine Blood Protein Electrophoresis medicine.disease Lipoproteins LDL Endocrinology Polyclonal antibodies Immunology biology.protein lipids (amino acids peptides and proteins) Antibody Protein Binding |
| Zdroj: | European Journal of Clinical Investigation. 2:342-347 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1972.tb00660.x |
| Popis: | In a 19 year old patient, presenting a severe hypo-β-lipoproteinaemia and a polyclonal IgG gammopathy, all known causes of hypo-β-lipoproteinaemia could be excluded. The patient's IgG reacted with homologous and autologous low density lipoproteins like an antibody, the binding activity being localized in the Fab fragment of the IgG molecule. The reactive part of LDL appeared to be the protein moiety (apoprotein LDL). Turnover studies with radioiodinated LDL showed that the reduction of the LDL concentration in the patient's serum was due to a decreased synthesis of LDL and also possibly to an immunelimination of LDL. |
| Databáze: | OpenAIRE |
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