Antibiotics and antifungals in silicone oil
| Autor: | Ella H. Leung, J. Timothy Stout |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.drug_class
Antibiotics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endophthalmitis Silicone Silicone oil lcsh:Ophthalmology Amphotericin B medicine Antifungals Chromatography Chemistry biochemical phenomena metabolism and nutrition medicine.disease bacterial infections and mycoses Ophthalmology Amikacin lcsh:RE1-994 030221 ophthalmology & optometry Vancomycin Original Article Centistokes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Journal of Retina and Vitreous, Vol 5, Iss 1, Pp 1-5 (2019) International Journal of Retina and Vitreous |
| ISSN: | 2056-9920 |
| Popis: | Background Antimicrobials may be injected into silicone oil-filled eyes with endophthalmitis, but the interaction with oil is unclear. The purpose of the experiment is to determine whether vancomycin, amikacin, and amphotericin B mix with silicone oil. Methods Using the relative proportions of the human eye, 4 ml of 1000 centistokes silicone oil was centrifuged with 0.1 ml of vancomycin 1 mg/0.1 ml, amikacin 0.4 mg/0.1 ml, or amphotericin B 5 µg/0.1 ml in vitro and eluted. The aqueous was immediately analyzed with a liquid chromatographer/mass spectrometer and after 24 h. Results Within 24 h, a mean of 26.9 μmol/L of vancomycin, 0 nmol/L of amikacin, and 0 nmol/L of amphotericin B were recovered. When the concentrations of amikacin and amphotericin B were increased 100-fold, 0 nmol/L of amikacin and 75.7 µmol/L of amphotericin B were recovered. Conclusions Vancomycin and amphotericin B partially mixed with the silicone oil. Amikacin was not recovered from the antibiotic–silicone oil mixture. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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