IL-4 alone and in combination with IL-10 protects against blood-induced cartilage damage
| Autor: | J.A. van Roon, F.P.J.G. Lafeber, N.W. Jansen, M.E. van Meegeren, M. J. G. Wenting, A.C.W. van Wesel, G. Roosendaal |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Cartilage Articular Male medicine.medical_treatment Drug Evaluation Preclinical Biomedical Engineering Apoptosis Inflammation Chondrocyte Tissue Culture Techniques Andrology Chondrocytes Rheumatology Hemarthrosis Humans Medicine Receptors Interleukin-10 Orthopedics and Sports Medicine Interleukin 4 Aged Dose-Response Relationship Drug business.industry Cartilage Interleukin Drug Synergism Middle Aged Coculture Techniques Interleukin-10 Receptors Interleukin-4 Up-Regulation Interleukin 10 Dose–response relationship medicine.anatomical_structure Cytokine Joint hemorrhage Immunology Cytokines Female Proteoglycans Interleukin-4 Inflammation Mediators medicine.symptom business |
| Zdroj: | Osteoarthritis and Cartilage. 20:764-772 |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2012.04.002 |
| Popis: | SummaryObjectiveIt has been reported that interleukin (IL)-10 limits blood-induced cartilage damage. Our aim was to study the effect of IL-4 alone and in combination with IL-10 on blood-induced cartilage damage.DesignHealthy human full thickness cartilage explants were cultured for 4 days in the presence of 50% v/v blood. IL-4, IL-10, or a combination of both cytokines was added during blood exposure. Cartilage matrix turnover was determined after a recovery period; additionally cytokine production, chondrocyte apoptosis, and expression of the IL-4 and IL-10 receptors were analyzed directly after exposure.ResultsBlood-induced damage to the cartilage matrix was limited by IL-4 in a dose-dependent way (P |
| Databáze: | OpenAIRE |
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