Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks
| Autor: | Shingo Suzuki, Fumihiko Maekawa, Kohichi Tanaka, Keiko Suzuki, Hayato Sugiyama, Tomoharu Nakamori, Hiroko Ohki-Hamazaki, Tomoyuki Kanamatsu |
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| Rok vydání: | 2012 |
| Předmět: |
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Western Imprinting Psychological In situ hybridization Tropomyosin receptor kinase B Transfection Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Neurotrophic factors Animals Humans Receptor trkB Visual Pathways RNA Messenger Imprinting (psychology) In Situ Hybridization Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor Critical Period Psychological Tyrosine phosphorylation Immunohistochemistry HEK293 Cells nervous system chemistry Trk receptor K252a Chickens Neuroscience |
| Zdroj: | Journal of Neurochemistry. 123:800-810 |
| ISSN: | 0022-3042 |
| DOI: | 10.1111/jnc.12039 |
| Popis: | With the aim of elucidating the neural mechanisms of early learning, we studied the role of brain-derived neurotrophic factor (BDNF) in visual imprinting in birds. The telencephalic neural circuit connecting the visual Wulst and intermediate medial mesopallium is critical for imprinting, and the core region of the hyperpallium densocellulare (HDCo), situated at the center of this circuit, has a key role in regulating the activity of the circuit. We found that the number of BDNF mRNA-positive cells in the HDCo was elevated during the critical period, particularly at its onset, on the day of hatching (P0). After imprinting training on P1, BDNF mRNA-positive cells in the HDCo increased in number, and tyrosine phosphorylation of TrkB was observed. BDNF infusion into the HDCo at P1 induced imprinting, even with a weak training protocol that does not normally induce imprinting. In contrast, K252a, an antagonist of Trk, inhibited imprinting. Injection of BDNF at P7, after the critical period, did not elicit imprinting. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period. |
| Databáze: | OpenAIRE |
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