Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
| Autor: | Hans J. Kaper, Arjan Vissink, Jeroen Vinke, Prashant K. Sharma |
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| Přispěvatelé: | Translational Immunology Groningen (TRIGR), Personalized Healthcare Technology (PHT), Man, Biomaterials and Microbes (MBM) |
| Rok vydání: | 2020 |
| Předmět: |
Quality of life
Saliva Friction Swine Biotribology DIAGNOSIS Positive correlation Oral cavity GLAND DYSFUNCTION Xerostomia Objective assessment 03 medical and health sciences 0302 clinical medicine Adsorption stomatognathic system MEDICATION Lubrication MANAGEMENT medicine Animals Humans Saliva substitutes Food science Salivary Proteins and Peptides Dental Enamel General Dentistry Chemistry Saliva Artificial Correction 030206 dentistry EFFICACY Dry mouth PREVALENCE stomatognathic diseases Ageing Original Article Salivary lubrication TRIAL WORLD WORKSHOP medicine.symptom 030217 neurology & neurosurgery Xanthan gum medicine.drug |
| Zdroj: | Clin Oral Investig Clinical Oral Investigations Clinical Oral Investigations, 24(11), 4019-4030. SPRINGER HEIDELBERG |
| ISSN: | 1436-3771 1432-6981 |
| DOI: | 10.1007/s00784-020-03272-x |
| Popis: | Objectives The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). Materials and methods Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances. Results Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption. Conclusions The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication. Clinical relevance This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes. |
| Databáze: | OpenAIRE |
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