A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge
| Autor: | Nicola Richardson-Harman, Yuhong Xiao, Louis J. DeTolla, George W. Buchman, Stuart N. Isaacs, Peter Silvera, Gary H. Cohen, Roselyn J. Eisenberg, Matthew E. Cohen, Heather L. Davis |
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| Rok vydání: | 2010 |
| Předmět: |
Male
animal diseases viruses Aluminum Hydroxide Enzyme-Linked Immunosorbent Assay Poxviridae Infections Antibodies Viral complex mixtures Article Monkeypox chemistry.chemical_compound Adjuvants Immunologic Viral Envelope Proteins Neutralization Tests medicine Animals Smallpox Poxviridae Orthopoxvirus Monkeypox virus Smallpox vaccine Antigens Viral General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health virus diseases medicine.disease biology.organism_classification Virology Vaccination Macaca fascicularis Infectious Diseases Oligodeoxyribonucleotides chemistry Immunoglobulin G Antibody Formation Vaccines Subunit Immunology Molecular Medicine Female Vaccinia Smallpox Vaccine |
| Zdroj: | Vaccine. 28:6627-6636 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2010.07.030 |
| Popis: | Concerns about infections caused by orthopoxviruses, such as variola and monkeypox viruses, drive ongoing efforts to develop novel smallpox vaccines that are both effective and safe to use in diverse populations. A subunit smallpox vaccine comprising vaccinia virus membrane proteins A33, B5, L1, A27 and aluminum hydroxide (alum) ± CpG were administered to non-human primates, which were subsequently challenged with a lethal intravenous dose of monkeypox virus. Alum-adjuvanted vaccines provided only partial protection but the addition of CpG provided full protection that was associated with a more homogeneous antibody response and stronger IgG1 responses. These results indicate that it is feasible to develop a highly effective subunit vaccine against orthopoxvirus infections as a safer alternative to live vaccinia virus vaccination. |
| Databáze: | OpenAIRE |
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