Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture
| Autor: | Hideaki Iwasa, Shigeo Mori, Kazuko Fujimoto, Koichiro Kawashima, Toshio Masuzawa, Naoshi Yamada, Norikazu Kurokawa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Light Urology Eye Pineal Gland Melatonin Normal pressure hydrocephalus medicine Humans Dilated third ventricle Circadian rhythm Melatonin secretion Cerebral Hemorrhage Rupture Spontaneous business.industry Intracranial Aneurysm Radioimmunoassay Venous blood Middle Aged medicine.disease Cerebrospinal Fluid Shunts Hydrocephalus Normal Pressure Circadian Rhythm Anesthesia Female Surgery Neurology (clinical) business Cerebral aneurysm rupture medicine.drug |
| Zdroj: | Neurologia medico-chirurgica. 31:490-497 |
| ISSN: | 1349-8029 0470-8105 |
| DOI: | 10.2176/nmc.31.490 |
| Popis: | Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients' MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle. |
| Databáze: | OpenAIRE |
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