Sex hormone receptors in mammary tumours of GR mice
| Autor: | Mels Sluyser, C.C.J. De Goeij, Siegina G. Evers |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Hormone Responsive medicine.medical_specialty Multidisciplinary Estrone Substance-Related Disorders Mammary Neoplasms Experimental Sex hormone receptor Biology Androgen receptor Mice Endocrinology Hormone receptor Internal medicine Progesterone receptor medicine Animals Humans Endocrine system Moiety Female Castration Neoplasm Transplantation Progesterone Hormone |
| Zdroj: | Nature. 263:386-389 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/263386a0 |
| Popis: | Studies of the growth behaviour and hormone receptor contents of GR-mouse mammary tumours suggest that the hormone responsive tumours are mixed populations of hormone-dependent cells and autonomous cells. The hormone-dependent moiety of these tumours contains high levels of progesterone receptor and oestrogen receptor. The autonomous moiety has a low but probably significant oestrogen receptor level, and is practically devoid of progesterone receptor. Androgen receptor levels in both moieties are low. Endocrine ablation prevents growth of the hormone-dependent moiety of the tumours, but not of the autonomous moiety. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|