Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement
| Autor: | Philip Scheltens, W.M. van der Flier, Reina W. Kloet, Frederik Barkhof, Albert D. Windhorst, Marissa D. Zwan, Ronald Boellaard, Rik Ossenkoppele, Sofie F. Adriaanse, Nelleke Tolboom, B.N.M. van Berckel, Adriaan A. Lammertsma, D.M.E. van Assema |
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| Přispěvatelé: | Neurology, Radiology and nuclear medicine, NCA - Neurodegeneration |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology Amyloid Genotype Posterior parietal cortex Standardized uptake value Neuropsychological Tests Gastroenterology chemistry.chemical_compound Apolipoproteins E Alzheimer Disease Fluorodeoxyglucose F18 Internal medicine Parietal Lobe medicine Dementia Humans Early-onset Alzheimer's disease Carbon Radioisotopes Age of Onset Aged Fluorodeoxyglucose Brain Mapping Aniline Compounds Parietal lobe Middle Aged medicine.disease Magnetic Resonance Imaging Thiazoles Glucose chemistry Case-Control Studies Positron-Emission Tomography Female Neurology (clinical) Age of onset Radiopharmaceuticals Psychology Pittsburgh compound B Cognition Disorders medicine.drug |
| Zdroj: | Ossenkoppele, R, Zwan, M D, Tolboom, N, van Assema, D M E, Adriaanse, S F, Kloet, R W, Boellaard, R, Windhorst, A D, Barkhof, F, Lammertsma, A A, Scheltens, P, van der Flier, W M & van Berckel, B N M 2012, ' Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement ', Brain, vol. 135, pp. 2115-2125 . https://doi.org/10.1093/brain/aws113 Brain, 135, 2115-2125. Oxford University Press |
| ISSN: | 0006-8950 |
| DOI: | 10.1093/brain/aws113 |
| Popis: | Alzheimer's disease with early onset often presents with a distinct cognitive profile, potentially reflecting a different distribution of underlying neuropathology. The purpose of this study was to examine the relationships between age and both in vivo fibrillary amyloid deposition and glucose metabolism in patients with Alzheimer's disease. Dynamic [(11)C]Pittsburgh compound-B (90 min) and static [(18)F]fluorodeoxyglucose (15 min) scans were obtained in 100 patients with Alzheimer's disease and 20 healthy controls. Parametric non-displaceable binding potential images of [(11)C]Pittsburgh compound-B and standardized uptake value ratio images of [(18)F]fluorodeoxyglucose were generated using cerebellar grey matter as reference tissue. Nine [(11)C]Pittsburgh compound-B-negative patients were excluded. The remaining patients were categorized into younger (n=45, age: 56 ± 4 years) and older (n=46, age: 69 ± 5 years) groups, based on the median age (62 years) at time of diagnosis. Younger patients showed more severe impairment on visuo-spatial function, attention and executive function composite scores (P |
| Databáze: | OpenAIRE |
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