Differential prognostic relevance of patho-anatomical factors among different tumor-biological subsets of breast cancer: Results from the adjuvant SUCCESS A study
| Autor: | Viktoria Aivazova-Fuchs, Andreas Schneeweiss, Kristina Ernst, Bernd Kost, Brigitte Rack, Julia Kathrin Jueckstock, Tobias Weissenbacher, Amelie deGregorio, Peter A. Fasching, Ullrich Andergassen, Wolfgang Janni, Iris Schrader, Matthias W. Beckmann, Lothar Häberle, Fabienne Schochter, E Bauer, Christoph Scholz, Inga Bekes, Miriam Deniz, Peter Widschwendter, Nikolaus DeGregorio, Julia Steidl, Thomas W. P. Friedl, Elisabeth Trapp |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Early detection Breast Neoplasms Triple Negative Breast Neoplasms Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Internal medicine Biomarkers Tumor Humans Medicine 030212 general & internal medicine Stage (cooking) Triple-negative breast cancer Aged Neoplasm Staging Retrospective Studies Tumor size business.industry General Medicine Middle Aged Prognosis medicine.disease Survival Rate Tumor Subtype 030220 oncology & carcinogenesis Female Surgery business NODAL Adjuvant |
| Zdroj: | The Breast. 44:81-89 |
| ISSN: | 0960-9776 |
| DOI: | 10.1016/j.breast.2018.12.008 |
| Popis: | In breast cancer, large tumor size, positive nodal stage and a triple-negative tumor subtype are associated with reduced survival, but the interactions between these prognostic factors are not well understood.Here we re-evaluated the impact of tumor size, nodal stage and tumor subtype on disease-free survival (DFS), overall survival (OS), distant disease-free survival (DDFS) and breast cancer specific survival (BCSS) in a retrospective analysis using data from the adjuvant SUCCESS A trial. Subgroup analyses were conducted to assess whether the effect of tumor size and nodal stage on survival depended on tumor subtype.Increasing tumor size, higher nodal stage and triple negative breast cancer (TNBC) were associated with unfavorable prognosis (all p 0.001). There was no significant interaction between tumor subtype and tumor size (p 0.5 for all four survival endpoints), but we found significant interactions between tumor subtype and nodal stage (p 0.05 for all four survival endpoints), with no differences in survival among tumor subtypes for patients with pN0 tumors (all p 0.05) and pronounced differences in survival among tumor subtypes for patients with positive nodal stage (all p 0.001).This analysis confirms tumor size, nodal stage and tumor subtype as independent prognostic factors in high-risk early breast cancer. Nodal-positive patients with TNBC had a considerably worse outcome compared to nodal-positive patients with another tumor subtype. This underlines the importance for early detection particularly for patients with TNBC.EudraCT 2005-000490-21; ClinicalTrials.gov Identifier: NCT02181101. |
| Databáze: | OpenAIRE |
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