Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A

Autor:	Joanne V. Gilbert, Capra Jd, Artenstein Ms, Andrew G. Plaut
Rok vydání:	1975
Předmět:	Immunoglobulin A Multidisciplinary biology Neisseria meningitidis Proteolytic enzymes medicine.disease_cause Subclass Neisseria gonorrhoeae Microbiology Blood serum Immunoglobulin A Secretory medicine biology.protein Peptide bond Humans Antibody Peptide Hydrolases
Zdroj:	Science (New York, N.Y.). 190(4219)
ISSN:	0036-8075
Popis:	The gonococcus and meningococcus, which infect human mucosal surfaces, elaborate a highly specific proteolytic enzyme which cleaves the immunoglobulin A1 subclass of the principal mucosal antibody, immunoglobulin A (IgA). The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9de4d0e3ed07d3d1335c1a2ef9d637 https://pubmed.ncbi.nlm.nih.gov/810892 Zobrazit plný text záznamu